Daboia russelii russelii (Indian Russell’s viper) is the common species in India and Pakistan. Lupus Anticoagulant. A Note on the Action of Heparin on Russell's Viper Venom. Although, as is obvious, there are many mechanisms of action for just one venom, it is convenient to classify venoms according to the composition and main modes of action. LA (non-specific inhibitors) are antibodies that block phospholipid surfaces and reduce the coagulant potential of plasma, thus prolonging in vitro clotting assays such as the PTT, the dilute Russell viper venom time (dRVVT) and the kaolin clotting time. It has a well-developed dentition and venom apparatus suitable for inflicting a deadly bite [3]. Russell’s viper venom-factor X activator (RVV-X) has been identified as a main procoagulant enzyme involving coagulopathy, which might be responsible for changes in renal hemodynamics and renal functions. The venom contains the enzymes RVV-V and RVV-X which activate factor V and factor X, which converts prothrombin into thrombin in the presence of phospholipid and calcium.. X produced by the intrinsic pathway, Russell’s viper venom, pro- longed incubation of Factor X in 25% sodium citrate, and by the action of tissue factor. Slow Mo! Envenoming by Russell's viper caused a marked rise in FPA, B beta 15‐42 fragment and fibrin derived cross‐linked D‐dimer fragment indicative of a consumptive coagulopathy with hyperfibrinolysis. The venom contains the enzymes RVV-V and RVV-X which activate factor V and factor X, which converts prothrombin into thrombin in the presence of phospholipid and calcium. Acute renal failure (ARF) is the most frequent and a serious complication in victims of Russell’s viper snakebites. Author(s) : GANGULY, S. N. Journal article : Indian Journal of Medical Research 1936 Vol.24 No.2 pp.525-529 pp. Watch this amazing footage of a Russell's Viper repeatedly striking - you'll never walk barefoot again! Lupus Anticoagulants. In the dRVVT assay, low, rate-limiting concentrations of both Russell's viper venom and phospholipid are used to give a standard clotting time of 30 to 40 seconds. Our … (7) This makes the test sensitive to the presence of lupus anticoagulants, because these antibodies interfere with the clot-promoting role of phospholipid in vitro, and their presence results in a prolonged clotting time. These investigators concluded that the forms of X, produced by each of these methods had identical molecular weights and NH2-terminal amino acids. Venom of Russell’s viper can induce neurotoxicity, myotoxicity, haemolysis, coagulopathy, renal

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